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pentobarbital will lessen the extent or influence of tamoxifen by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.pentobarbital raises effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers may perhaps enhance metabolism of ifosfamide